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How does herpes affect your penis and what are the long-term effects on a Alternatively, if you have already been diagnosed with genital herpes, you can. Genital herpes is an infection by herpes simplex virus (HSV) of the genitals. Most people either In males, the lesions occur on the glans penis, shaft of the penis or other parts of the genital region, on . There are efforts to develop a vaccine, but the results so far have not been able to cure herpes or eliminate transmission.